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Article

Niflumic Acid Suppresses Interleukin-13–induced Asthma Phenotypes

9 Mar 2006

Abstract excerpt

RATIONALE: Chloride channels have been implicated in the regulation of mucus production in epithelial cells. Expression of hCLCA1, a calcium-activated chloride channel, has been reported to be increased in the airway epithelium of patients with asthma. Interleukin (IL)-13 induces the cardinal features of bronchial asthma, and glucocorticoids are not sufficient to suppress IL-13-induced airway hyperresponsiveness...

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PMID: 16528019
DOI: 10.1164/rccm.200410-1420oc

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