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Article

IL-4 Receptor Signaling in Clara Cells Is Required for Allergen-Induced Mucus Production

1 Sept 2005

Abstract excerpt

Excessive mucus production is an important pathological feature of asthma. The Th2 cytokines IL-4 and IL-13 have both been implicated in allergen-induced mucus production, inflammation, and airway hyperreactivity. Both of these cytokines use receptors that contain the IL-4Ralpha subunit, and these receptors are expressed on many cell types in the lung. It has been difficult to determine whether allergen-induced...

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PMID: 16148120
DOI: 10.4049/jimmunol.175.6.3746

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