Article
Sequence variations in the DNA repair gene XPD and risk of lung cancer in a Chinese population.
International journal of cancer - 10 Jul 2003
Liang Gang, Xing Deyin, Miao Xiaoping, Tan Wen, Yu Chunyuan, Lu Wenfu, Lin Dongxin
Abstract excerpt
Variation in DNA repair capacity, which is believed to be largely determined by genetic traits, is linked to risk of certain cancers. The Asp312Asn and Lys751Gln polymorphisms in the xeroderma pigmentosum complementary group D (XPD) gene may alter DNA repair capacity. We thus examined the hypothesis that these 2 XPD polymorphisms are associated with risk of lung cancer via a large hospital-based, case-control...
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