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Article

Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability.

The Journal of biological chemistry - 16 Nov 2001

Maurice D, Pierreux C E, Howell M, Wilentz R E, Owen M J, Hill C S

Abstract excerpt

At early stages of tumorigenesis, the transforming growth factor-beta (TGF-beta) signaling pathway is thought to have tumor suppressor activity as a result of its ability to arrest the growth of epithelial cells. Smad4 plays a pivotal role in the TGF-beta signaling pathway and has been identified as a tumor suppressor, being mutated or deleted in approximately 50% of pancreatic carcinomas and 15% of colorectal...

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Identifiers

PMID: 11553622
DOI: 10.1074/jbc.M105895200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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