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Article

Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.

The Journal of biological chemistry - 5 May 2006

Hiromasa Yasuaki, Hu Liangyan, Roche Thomas E

Abstract excerpt

Tryptophan fluorescence was used to analyze binding of ligands to human pyruvate dehydrogenase isoform 2 (PDHK2) and to demonstrate effects of ligand binding on distal structure of PDHK2 that is required for binding to the inner lipoyl domain (L2) of the dihydrolipoyl acetyltransferase. Ligand-altered binding of PDHK2 to L2 and effects of specific ligands on PDHK2 oligomeric state were characterized by analytical...

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Identifiers

PMID: 16517984
DOI: 10.1074/jbc.M513514200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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