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Article

Filamin A is reduced and contributes to the CASR sensitivity in human parathyroid tumors.

Journal of molecular endocrinology - 1 Feb 2017

Mingione Alessandra, Verdelli Chiara, Ferrero Stefano, Vaira Valentina, Guarnieri Vito, Scillitani Alfredo, Vicentini Leonardo, Balza Gianni, Beretta Edoardo, Terranegra Annalisa, Vezzoli Giuseppe, Soldati Laura, Corbetta Sabrina

Abstract excerpt

Parathyroid tumors display reduced sensitivity to extracellular calcium ([Ca2+]o). [Ca2+]o activates calcium-sensing receptor (CASR), which interacts with the scaffold protein filamin A (FLNA). The study aimed to investigate: (1) the FLNA expression in human parathyroid tumors, (2) its effects on the CASR mRNA and protein expression, and (3) on ERK signaling activation, (4) the effect of the carboxy-terminal CASR...

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Share to Extracellular Signal-Regulated MAP Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Gene Silencing

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Share to Receptors, Calcium-Sensing

Source

Identifiers

PMID: 27872158
DOI: 10.1530/JME-16-0184

Genes

CASR
FLNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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