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Article

Crystallization and diffraction properties of the Fab fragment of 3B5H10, an antibody specific for disease-causing polyglutamine stretches.

Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Dec 2005

Peters-Libeu Clare, Newhouse Yvonne, Krishnan Preethi, Cheung Kenneth, Brooks Elizabeth, Weisgraber Karl, Finkbeiner Steven

Abstract excerpt

Because it binds soluble forms of proteins with disease-associated polyglutamine expansions, the antibody 3B5H10 is a powerful tool for studying polyglutamine-related diseases. Crystals of the 3B5H10 Fab (47 kDa) were obtained by vapor diffusion at room temperature from PEG 3350. However, the initial crystals gave highly anisotropic diffraction patterns. After optimization of the crystallization conditions and...

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Identifiers

PMID: 16511236
DOI: 10.1107/S1744309105036547
PMCID: PMC1978161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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