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Article

The HLA-A1-B8 haplotype hitchhiking with the hemochromatosis mutation: does it affect the phenotype?

European journal of haematology - 1 Nov 2007

Olsson K Sigvard, Ritter Bernd, Hansson Norbeth

Abstract excerpt

BACKGROUND: Hemochromatosis is a recessively inherited disorder caused by a point mutation, C282Y of the HFE gene on chromosome 6p21.3 near the human leukocyte antigen (HLA) locus. It is unknown why some homozygotes develop a severe iron loading, while others do not. A recent study suggested that the A1-B8 haplotype may be associated with higher iron storage. METHODS: We studied HLA haplotypes of 85 probands, 31...

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Source

Identifiers

PMID: 17924859
DOI: 10.1111/j.1600-0609.2007.00953.x

Genes

HFE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The HLA-A1-B8 haplotype hitchhiking with the hemochromatosis mutation: does it affect the phenotype?PMID 17924859Read ↗

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