Article
A class of human exons with predicted distant branch points revealed by analysis of AG dinucleotide exclusion zones.
Genome biology - 1 Jan 2006
Gooding Clare, Clark Francis, Wollerton Matthew C, Grellscheid Sushma-Nagaraja, Groom Harriet, Smith Christopher W J
Abstract excerpt
BACKGROUND: The three consensus elements at the 3' end of human introns--the branch point sequence, the polypyrimidine tract, and the 3' splice site AG dinucleotide--are usually closely spaced within the final 40 nucleotides of the intron. However, the branch point sequence and polypyrimidine tract of a few known alternatively spliced exons lie up to 400 nucleotides upstream of the 3' splice site. The extended...
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