Article
Utility of molecular genetic signatures in the delineation of gastric neoplasia.
Cancer - 1 Apr 2006
Kidd Mark, Modlin Irvin M, Mane Shrikant M, Camp Robert L, Eick Geeta N, Latich Igor, Zikusoka Michelle N
Abstract excerpt
BACKGROUND: Current techniques to define gastric neoplasia are limited but molecular genetic signatures can categorize tumors and provide biological rationale for predicting clinical behavior. We identified three gene signatures: Chromogranin A (CgA), MAGE-D2 (adhesion), and MTA1 (metastasis) that define gastrointestinal (GI) carcinoids and hypothesize that their expression can delineate gastric neoplasia. This...
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