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Combined Use of Helicobacter pylori Genotyping and CDX2 Expression as a Predictor of Malignant Potential in Gastric Intestinal Metaplasia.

Annals of clinical and laboratory science - 1 Jan 2024

Zhang Mengyuan, Zhang Zhong, Jiao Lanlan, Liang Li, Bo Wei, Zhang Min, Li Xiaobo, Fu Xingwei, Wang Xuguang

Abstract excerpt

OBJECTIVE: Gastrointestinal metaplasia (GIM) has a close relationship with gastric cancer (GC), but it is unclear how to judge which GIM could develop into GC. This study aimed to assess the role of CDX2 and its association with Helicobacter pylori (H.pylori) genotypes in GIM. METHODS: CagA and vacA genes were identified via PCR in 466 H. pylori-positive gastric tissues, including gastritis (n=104), GIM diagnosed...

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PMID: 38514066

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