Article
Reduced expression of the endothelin receptor type B gene in piebald mice caused by insertion of a retroposon-like element in intron 1.
The Journal of biological chemistry - 21 Apr 2006
Yamada Takahisa, Ohtani Shin, Sakurai Takeshi, Tsuji Takehito, Kunieda Tetsuo, Yanagisawa Masashi
Abstract excerpt
Mice carrying the piebald mutation exhibit white coat spotting due to the regional absence of neural crest-derived melanocytes. We reported previously that the piebald locus encodes the Ednrb gene and that piebald mice express low levels of structurally intact Ednrb mRNA and EDNRB protein (Hosoda, K., Hammer, R. E., Richardson, J. A., Baynash, A. G., Cheung, J. C., Giaid, A., and Yanagisawa, M. (1994) Cell 79,...
Topics
- Alleles
- Alternative Splicing
- Animals
- Base Sequence
- Blotting, Northern
- COS Cells
- Cell Line, Tumor
- Chlorocebus aethiops
- DNA, Complementary
- Exons
- Gene Expression Regulation
- Genes, Reporter
- Genetic Vectors