Article
Dopamine D3-receptor gene variant and susceptibility to tardive dyskinesia in schizophrenic patients.
Molecular psychiatry - 1 Mar 1997
Steen V M, Løvlie R, MacEwan T, McCreadie R G
Abstract excerpt
Schizophrenia is a serious psychiatric illness with a life-time risk of approximately one percent. Many of the patients, but not all, benefit from treatment with anti-psychotic drugs known to block dopamine D2-like receptors. The use of conventional neuroleptics is, however, hampered by the risk of extrapyramidal side-effects. Tardive dyskinesia (TD) is usually regarded as the most serious of these drug-induced...
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