Back to search

Article

Oxidative stress and vacuolar variants influence paraquat response in <i>Saccharomyces cerevisiae</i> of different genetic variants

2025-05-31

Abstract excerpt

The biological effects of paraquat (PQ), an herbicide linked to Parkinson’s disease (PD) risk in humans can be studied in Saccharomyces cerevisiae due to its evolutionary conservation with mammals. To understand how genetic background influences PQ toxicity, we treated four yeast strains (NA, SA, WA, and WE) with PQ and assessed physiological (growth curves), molecular (superoxide and peroxide levels) and cellula...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
da07df6c-9d4c-546d-a72b-f4958630db8d
DOI
10.1101/2025.05.27.656361
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Oxidative stress and vacuolar variants influence paraquat response in <i>Saccharomyces cerevisiae</i> of different genetic variantsDOI 10.1101/2025.05.27.656361
The Role of the Parkinson's Disease Gene PARK9 in Essential Cellular Pathways and the Manganese Homeostasis Network in YeastSemantic proximity
Genome-wide analysis reveals genes mediating resistance to paraquat neurodegeneration in <i>Drosophila</i>Semantic proximity
Complex trait analysis with a multi-species approach to disentangle genetic modulators of cellular growth phenotypes under disease-relevant treatmentsSemantic proximity
Mitochondrial ribosomal proteins involved in tellurite resistance in yeast Saccharomyces cerevisiae.Semantic proximity
Induction of phenotypes resembling CuZn-superoxide dismutase deletion in wild-type yeast cells: an in vivo assay for the role of superoxide in the toxicity of redox-cycling compounds.Semantic proximity
Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in Saccharomyces cerevisiae.Semantic proximity
Single cell functional genomics reveals the importance of mitochondria in cell-to-cell variation in proliferation, drug resistance and mutation outcomeSemantic proximity
Yhk8 as a genomic modifier of copper susceptibility in yeastSemantic proximity
Genome-wide screen of genes required for caffeine tolerance in fission yeast.Semantic proximity
A genome-wide nanotoxicology screen of Saccharomyces cerevisiae mutants reveals the basis for cadmium sulphide quantum dot tolerance and sensitivity.Semantic proximity
The complex genetic and molecular basis of a model quantitative trait.Semantic proximity
Genetic variation in Dip5, an amino acid permease, and Pdr5, a multiple drug transporter, regulates glyphosate resistance in S. cerevisiae.Semantic proximity
Select a neighboring publication to make it the new centre.