Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Paget's disease.

doi:10.1016/j.cmet.2010.12.002

Article

Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Paget's disease.

Cell metabolism - 5 Jan 2011

Kurihara Noriyoshi, Hiruma Yuko, Yamana Kei, Michou Laëtitia, Rousseau Côme, Morissette Jean, Galson Deborah L, Teramachi Jumpei, Zhou Hua, Dempster David W, Windle Jolene J, Brown Jacques P, Roodman G David

Abstract excerpt

Paget's disease (PD) is characterized by abnormal osteoclasts (OCL) that secrete high IL-6 levels and induce exuberant bone formation. Because measles virus nucleocapsid gene (MVNP) and the p62(P392L) mutation are implicated in PD, marrows from 12 PD patients harboring p62(P392L) and eight normals were tested for MVNP expression and pagetic OCL formation. Eight out of twelve patients expressed MVNP and formed...

Topics

Adaptor Proteins, Signal Transducing
Animals
Bone Marrow Cells
Bone and Bones
Calcitriol
Cells, Cultured
Female
Gene Expression
Humans
Interleukin-6

Measles virus

Mice

Mice, Transgenic

Middle Aged

Mutation

Nucleocapsid

Nucleocapsid Proteins

Osteitis Deformans

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