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Article

Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2014

Teramachi Jumpei, Zhou Hua, Subler Mark A, Kitagawa Yukiko, Galson Deborah L, Dempster David W, Windle Jolene J, Kurihara Noriyoshi, Roodman G David

Abstract excerpt

Measles virus nucleocapsid protein (MVNP) expression in osteoclasts (OCLs) and mutation of the SQSTM1 (p62) gene contribute to the increased OCL activity in Paget's disease (PD). OCLs expressing MVNP display many of the features of PD OCLs. Interleukin-6 (IL-6) production is essential for the pagetic phenotype, because transgenic mice with MVNP targeted to OCLs develop pagetic OCLs and lesions, but this phenotype...

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Identifiers

PMID: 24339057
DOI: 10.1002/jbmr.2158
PMCID: PMC4361000

Genes

SQSTM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone.PMID 24339057Read ↗

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Osteoclasts formed by measles virus-infected osteoclast precursors from hCD46 transgenic mice express characteristics of pagetic osteoclasts.Semantic proximity Read ↗

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Zoledronic acid prevents pagetic-like lesions and accelerated bone loss in the p62P394L mouse model of Paget's disease.Semantic proximity Read ↗

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