Article
Constitutive expression and role in growth regulation of interleukin-1 and multiple cytokine receptors in a biphenotypic leukemic cell line.
Blood - 1 Jul 1991
Cohen A, Grunberger T, Vanek W, Dube I D, Doherty P J, Letarte M, Roifman C, Freedman M H
Abstract excerpt
A cell line (B1) was established from the bone marrow of a patient with a relapse of acute leukemia characterized by a 4;11 chromosomal translocation and biphenotypic features of early B and myeloid lineages. Analysis of the growth requirements of this cell line showed density-dependent growth and secretion of an autostimulatory growth factor, suggesting an autocrine mechanism. Several lines of evidence implicate...
Topics
- Acute Disease
- Adolescent
- Base Sequence
- Bone Marrow
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 4
- DNA
- Enzyme-Linked Immunosorbent Assay
- Gene Expression
- Humans
- Interleukin-1