Article
Fitness evolution and the rise of mutator alleles in experimental Escherichia coli populations.
Genetics - 1 Oct 2002
Shaver Aaron C, Dombrowski Peter G, Sweeney Joseph Y, Treis Tania, Zappala Renata M, Sniegowski Paul D
Abstract excerpt
We studied the evolution of high mutation rates and the evolution of fitness in three experimental populations of Escherichia coli adapting to a glucose-limited environment. We identified the mutations responsible for the high mutation rates and show that their rate of substitution in all three p...
Topics
- Adenosine Triphosphatases
- Bacterial Proteins
- Base Pair Mismatch
- Biological Evolution
- DNA Repair
- DNA-Binding Proteins
- Escherichia coli
- Escherichia coli Proteins
- MutL Proteins
- MutS DNA Mismatch-Binding Protein
- Mutation