Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fitness evolution and the rise of mutator alleles in experimental Escherichia coli populations.

Genetics - 1 Oct 2002

Shaver Aaron C, Dombrowski Peter G, Sweeney Joseph Y, Treis Tania, Zappala Renata M, Sniegowski Paul D

Abstract excerpt

We studied the evolution of high mutation rates and the evolution of fitness in three experimental populations of Escherichia coli adapting to a glucose-limited environment. We identified the mutations responsible for the high mutation rates and show that their rate of substitution in all three populations was too rapid to be accounted for simply by genetic drift. In two of the populations, large gains in fitness...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Biological Evolution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to DNA Repair

Share to Escherichia coli

Share to Escherichia coli Proteins

Share to Mutation

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 12399371
DOI: 10.1093/genetics/162.2.557
PMCID: PMC1462288

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fitness evolution and the rise of mutator alleles in experimental Escherichia coli populations.PMID 12399371Read ↗

Clonal interference and the periodic selection of new beneficial mutations in Escherichia coli.Semantic proximity Read ↗

Mutation accumulation and fitness in mutator subpopulations of Escherichia coli.Semantic proximity Read ↗

Evolution of high mutation rates in experimental populations of E. coli.Semantic proximity Read ↗

Rate and effects of spontaneous mutations that affect fitness in mutator Escherichia coli.Semantic proximity Read ↗

Competition between high- and higher-mutating strains of Escherichia coli.Semantic proximity Read ↗

Role of mutator alleles in adaptive evolution.Semantic proximity Read ↗

Mutational spectrum drives the rise of mutator bacteria.Semantic proximity Read ↗

High mutation rates limit evolutionary adaptation in Escherichia coli.Semantic proximity Read ↗

Mutator genomes decay, despite sustained fitness gains, in a long-term experiment with bacteria.Semantic proximity Read ↗

Emergence of a multilocus mutator genotype in mutator Escherichia coli experimental populations under repeated lethal selection.Semantic proximity Read ↗

Mutation rate variability as a driving force in adaptive evolutionSemantic proximity Read ↗

The dynamics of adaptation on correlated fitness landscapes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.