Article
Specific polymorphisms of cytokine genes are associated with different risks to develop single-system or multi-system childhood Langerhans cell histiocytosis.
British journal of haematology - 1 Mar 2006
De Filippi Paola, Badulli Carla, Cuccia Mariaclara, De Silvestri Annalisa, Dametto Ennia, Pasi Annamaria, Garaventa Alberto, del Prever Adalberto Brach, Todesco Alessandra, Trizzino Antonino, Danesino Cesare, Martinetti Miryam, Aricò Maurizio
Abstract excerpt
Cytokines and chemokines determine mobilisation of Langerhans cells and their dysregulation is implicated in the pathogenesis of Langerhans cell histiocytosis (LCH). Twenty point mutations of 12 different cytokine genes were studied in 41 Italian children, 15 with single-system (SS) and 26 with multi-system disease. The allele and genotype distributions of interleukin-4 (IL-4) and interferon-gamma (IFNgamma) were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.