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Article

Inflammatory serum cytokines and chemokines increase associated with the disease extent in pediatric Langerhans cell histiocytosis.

Cytokine - 1 Sept 2017

Morimoto Akira, Oh Yukiko, Nakamura Sachie, Shioda Yoko, Hayase Tomomi, Imamura Toshihiko, Kudo Kazuko, Imashuku Shinsaku

Abstract excerpt

OBJECTIVE: Langerhans cell histiocytosis (LCH) is characterized by immature dendritic cell proliferation, infiltration of LCH lesions by various inflammatory cells, and a lesional cytokine storm. It is classified into three groups on the basis of disease extent, namely, multisystem with risk-organ involvement (MS+), multisystem without risk-organ involvement (MS-), and single-system (SS) disease. We...

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Source

Identifiers

PMID: 28582647
DOI: 10.1016/j.cyto.2017.05.026

Genes

BRAF
CCL2
CCL7
CXCL1
CXCL9
HGF
MIF
CCL3
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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