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Article

Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain-like behaviour.

Journal of neurochemistry - 1 Nov 2006

Hobson Sally-Ann, Holmes Fiona E, Kerr Niall C H, Pope Robert J P, Wynick David

Abstract excerpt

Expression of the neuropeptide galanin is markedly up-regulated within the adult dorsal root ganglia (DRG) following peripheral nerve injury. We have previously demonstrated that galanin knockout (Gal-KO) mice have a developmental loss of a subset of DRG neurons. Galanin also plays a trophic role in the adult animal, and the rate of peripheral nerve regeneration and neurite outgrowth is reduced in adult Gal-KO...

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Identifiers

PMID: 17076662
DOI: 10.1111/j.1471-4159.2006.04143.x
PMCID: PMC2725756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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