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Article

Role of transforming growth factor-beta in hematologic malignancies.

Blood - 15 Jun 2006

Dong Mei, Blobe Gerard C

Abstract excerpt

The transforming growth factor-beta (TGF-beta) signaling pathway is an essential regulator of cellular processes, including proliferation, differentiation, migration, and cell survival. During hematopoiesis, the TGF-beta signaling pathway is a potent negative regulator of proliferation while stimulating differentiation and apoptosis when appropriate. In hematologic malignancies, including leukemias,...

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Source

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Identifiers

PMID: 16484590
DOI: 10.1182/blood-2005-10-4169
PMCID: PMC1895802

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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