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Article

Involvement of Niemann-Pick type C2 protein in hematopoiesis regulation.

Stem cells (Dayton, Ohio) - 1 Jun 2006

Heo Kyu, Jariwala Unnati, Woo Jeongim, Zhan Yuxia, Burke Kathleen A, Zhu Lunjian, Anderson W French, Zhao Yi

Abstract excerpt

Niemann-Pick type C2 (NPC2) protein has been characterized as a cholesterol-binding protein. Its loss leads to NPC2 disease, an inherited neurodegenerative disorder. When analyzing gene expression profile, we noticed high expression of both NPC2 and its receptor, mannose 6-phosphate receptor (MPR), in murine hematopoietic stem cells. NPC2 protein, in the presence of thrombopoietin (TPO), causes an increase in...

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Source

Identifiers

PMID: 16484344
DOI: 10.1634/stemcells.2005-0458

Genes

NPC2
TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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