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Article

Altered vitamin E status in Niemann-Pick type C disease.

Journal of lipid research - 1 Jul 2011

Ulatowski L, Parker R, Davidson C, Yanjanin N, Kelley T J, Corey D, Atkinson J, Porter F, Arai H, Walkley S U, Manor D

Abstract excerpt

Vitamin E (α-tocopherol) is the major lipid-soluble antioxidant in many species. Niemann-Pick type C (NPC) disease is a lysosomal storage disorder caused by mutations in the NPC1 or NPC2 gene, which regulates lipid transport through the endocytic pathway. NPC disease is characterized by massive intracellular accumulation of unesterified cholesterol and other lipids in lysosomal vesicles. We examined the roles...

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Source

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Identifiers

PMID: 21550990
DOI: 10.1194/jlr.M015560
PMCID: PMC3122910

Genes

NPC1
NPC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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