Article
Extracellular nucleoside diphosphate kinase NM23/NDPK modulates normal hematopoietic differentiation.
Experimental hematology - 1 Jul 2002
Willems Roel, Slegers Herman, Rodrigus Inez, Moulijn Adriaan C, Lenjou Marc, Nijs Griet, Berneman Zwi N, Van Bockstaele Dirk R
Abstract excerpt
OBJECTIVE: We previously demonstrated the presence of nucleoside diphosphate kinase NDPK/NM23 in normal human plasma. It also was reported that extracellular NM23 could inhibit differentiation of certain hematopoietic cell lines. We further investigated the extracellular effect of NM23 on hematopoiesis by adding recombinant NM23-H1, NM23-H2, and NM23-H3 proteins to in vitro differentiation assays of normal human...
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