Article
Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor.
Molecular pharmacology - 1 Jun 2006
Chen Xianghai, Chen Frank, Liu Shanjun, Glaeser Hartmut, Dawson Paul A, Hofmann Alan F, Kim Richard B, Shneider Benjamin L, Pang K Sandy
Abstract excerpt
Transactivation of the rat apical sodium-dependent bile acid transporter (ASBT; Slc10a2) by 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] via the vitamin D receptor (VDR), was studied. Levels of ASBT protein and mRNA were low in the duodenum and high in the ileum, and both were induced by 1,25(OH)(2)D(3). The nuclear receptor protein, VDR, was present uniformly in the duodenum, jejunum, and ileum of the rat...
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