Article
Telomere length and the expression of natural telomeric genes in human fibroblasts
21 May 2003
Abstract excerpt
Progressive telomere shortening occurs with division of normal human cells, and eventually leads to replicative senescence. The mechanism by which the shortened telomeres cause growth arrest is largely unknown. Transcriptional silencing of genes adjacent to telomeres, also called telomere position effect, has been hypothesized as a possible mechanism of telomere-mediated senescence. However, there is no report...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.