Article
Deficient alpha-1-antitrypsin phenotypes and persistent airflow limitation in severe asthma.
Respiratory medicine - 1 Sept 2006
van Veen Ilonka H, ten Brinke A, van der Linden A C, Rabe K F, Bel E H
Abstract excerpt
BACKGROUND: Persistent airflow limitation is common among patients with severe asthma, but its pathogenesis has not been fully clarified. Severe alpha-1-antitrypsin (AAT) deficiency is a risk factor of chronic airflow limitation and emphysema, and partially deficient phenotypes have been associated with an accelerated decline in lung function. We hypothesized that partial deficiency of AAT (non-PiM AAT phenotype)...
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