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Article

Variable contribution of the MTHFR C677T polymorphism to non-syndromic cleft lip and palate risk in China.

American journal of medical genetics. Part A - 15 Mar 2006

Zhu JiangHui, Ren AiGuo, Hao Ling, Pei LiJun, Liu JianMeng, Zhu HuiPing, Li Song, Finnell Richard H, Li Zhu

Abstract excerpt

Non-syndromic cleft lip with or without cleft palate (nsCL/P) is one of the most common craniofacial malformations among newborn infants. It has been demonstrated that periconceptional folic acid supplementation may reduce the occurrence of offspring with clefts, particularly in the North China; however, the mechanism remains unknown. Our study of a thermolabile polymorphism (C677T) of methylenetetrahydrofolate...

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Identifiers

PMID: 16470725
DOI: 10.1002/ajmg.a.31115

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Variable contribution of the MTHFR C677T polymorphism to non-syndromic cleft lip and palate risk in China.PMID 16470725Read ↗

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[Relationship between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and genetic polymorphisms of MTHFR C677T and A1298C].Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T polymorphism is not associated with the risk of nonsyndromic cleft lip/palate: An updated meta-analysis.Semantic proximity Read ↗

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[Relationship between genetic polymorphisms of MTHFR C677T and nonsyndromic cleft lip with or without palate].Semantic proximity Read ↗

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