Article
The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Apr 2006
Mattiske Deidre, Sommer Paula, Kidson Susan H, Hogan Brigid L M
Abstract excerpt
The lacrimal gland produces secretions that lubricate and protect the cornea of the eye. Foxc1 encodes a forkhead/winged helix transcription factor required for the development of many embryonic organs. Autosomal dominant mutations in human FOXC1 cause eye disorders such as Axenfeld-Rieger Syndrome and glaucoma iris hypoplasia, resulting from malformation of the anterior segment of the eye. We show here that...
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