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Article

Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice.

Development (Cambridge, England) - 1 Jul 1999

D'Souza R N, Aberg T, Gaikwad J, Cavender A, Owen M, Karsenty G, Thesleff I

Abstract excerpt

Osteoblasts and odontoblasts, cells that are responsible for the formation of bone and dentin matrices respectively, share several molecular characteristics. Recently, Cbfa1 was shown to be a critical transcriptional regulator of osteoblast differentiation. Mutations in this gene cause cleidocranial dysplasia (CCD), an autosomal dominant disorder in humans and mice characterized by defective bone formation. CCD...

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Source

Identifiers

PMID: 10357935
DOI: 10.1242/dev.126.13.2911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice.PMID 10357935Read ↗

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A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development.Semantic proximity Read ↗

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone DevelopmentSemantic proximity Read ↗

Cbfβ deletion in mice recapitulates cleidocranial dysplasia and reveals multiple functions of Cbfβ required for skeletal developmentSemantic proximity Read ↗

CBFA1: A molecular switch in osteoblast biologySemantic proximity Read ↗

Cbfb Regulates Bone Development by Stabilizing Runx Family ProteinsSemantic proximity Read ↗

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