Article
Differential requirements for alpha4 integrins during fetal and adult hematopoiesis.
Cell - 28 Jun 1996
Arroyo A G, Yang J T, Rayburn H, Hynes R O
Abstract excerpt
Mice chimeric for the expression of alpha4 integrins were used to dissect the roles of these receptors in development and traffic of lymphoid and myeloid cells. During fetal life, T cell development is alpha4 independent, but after birth further production of T cells becomes alpha4 dependent. Precursors for both T and B cells require alpha4 integrins for normal development within the bone marrow. In contrast,...
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