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Article

A mutation in aminopeptidase N (CD13) isolated from a patient suffering from leukemia leads to an arrest in the endoplasmic reticulum.

The Journal of biological chemistry - 28 Apr 2006

Alfalah Marwan, Krahn Michael P, Wetzel Gabi, von Hörsten Stephan, Wolke Carmen, Hooper Nigel, Kalinski Thomas, Krueger Sabine, Naim Hassan Y, Lendeckel Uwe

Abstract excerpt

Human aminopeptidase N (APN) is used as a routine marker for myelomonocytic cells in hematopoietic malignant disorders. Its gene and surface expressions are increased in cases of malignant transformation, inflammation, or T cell activation, whereas normal B and resting T cells lack detectable APN protein expression. In this study we elucidated the intracellular distribution, expression pattern, and enzymatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16469741
DOI: 10.1074/jbc.M511364200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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