Prolonged association of temperature-sensitive mutants of human P-glycoprotein with calnexin during biogenesis.

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Article

Prolonged association of temperature-sensitive mutants of human P-glycoprotein with calnexin during biogenesis.

The Journal of biological chemistry - 18 Nov 1994

Loo T W, Clarke D M

Abstract excerpt

Mutation of amino acids located within or immediately NH2-terminal to transmembrane segment 7 of human P-glycoprotein abolished the ability of the protein to confer resistance to cytotoxic drugs. Each of these mutant P-glycoproteins had an apparent mass of 150 kDa, compared with 170 kDa for wild-...

Topics

3T3 Cells
ATP Binding Cassette Transporter, Subfamily B, Member 1
Amino Acid Sequence
Animals
Calcium-Binding Proteins
Calnexin
Humans
Kinetics
Membrane Proteins
Mice
Molecular Sequence Data
Mutation
Protein Processing, Post-Translational
Temperature

Source

Open in PubMed

Identifiers

PMID: 7961819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7961819-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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