Article
Rheumatoid arthritis: a disease of chronic, low-amplitude signals transduced through T cell antigen receptors?
Wiener medizinische Wochenschrift (1946) - 1 Jan 2006
Zhang Zhuoli, Gorman Claire, Clark Joanna M, Cope Andrew P
Abstract excerpt
Technology has advanced to the stage where it is now possible to identify genes that confer low to moderate risk of developing autoimmune diseases such as rheumatoid arthritis (RA). This has been facilitated by the growing appreciation that these hard to detect genetic signals can only be defined in large cohorts of well characterized patients. In RA, the association between disease susceptibility and genes...
Topics
- Alleles
- Arthritis, Rheumatoid
- Genetic Predisposition to Disease
- Genetic Variation
- HLA-DR Antigens
- HLA-DRB1 Chains
- Histocompatibility Antigens Class II
- Humans
- Major Histocompatibility Complex
- Receptors, Antigen, T-Cell