Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations.

Abstract excerpt

Cerebral cavernous malformations are vascular defects of the central nervous system consisting of clusters of dilated vessels that are subject to frequent hemorrhaging. The genes mutated in three forms of autosomal dominant cerebral cavernous malformations have been cloned, but it remains unclear which cell type is ultimately responsible for the lesion. In this article we describe mice with a gene trap insertion...

Topics

• Animals
• Base Sequence
• Brain
• Central Nervous System Vascular Malformations
• Cerebral Hemorrhage
• Choroid Plexus
• Disease Models, Animal
• Endothelium, Vascular
• Heterozygote
• In Situ Hybridization