Article
Beta2-adrenoceptor genotype and function affect hemodynamic profile heterogeneity in postural tachycardia syndrome.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 2006
Jacob Giris, Garland Emily M, Costa Fernando, Stein C Michael, Xie Hong-Guang, Robertson Rose Marie, Biaggioni Italo, Robertson David
Abstract excerpt
Previous studies suggest that the beta2-adrenoceptor functions abnormally in patients with postural tachycardia syndrome (POTS) and may contribute to their altered hemodynamic profile. To test the hypothesis that the beta2-adrenoceptor response is decreased in POTS, we studied: (1) the arterial vasodilation response to the beta agonist, isoproterenol, and (2) the distribution of common polymorphisms (codons 16...
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