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Article

Regulation of methane monooxygenase catalysis based on size exclusion and quantum tunneling.

Biochemistry - 14 Feb 2006

Zheng Hui, Lipscomb John D

Abstract excerpt

The hydroxylase component (MMOH) of the soluble form of methane monooxygenase (sMMO) isolated from Methylosinus trichosporium OB3b catalyzes both the O2 activation and the CH4 oxidation reactions at the oxygen-bridged dinuclear iron cluster present in its buried active site. During the reaction cycle, the diiron cluster forms a bis-mu-oxo-(Fe(IV))2 intermediate termed compound Q (Q) that reacts directly with...

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PMID: 16460015
DOI: 10.1021/bi051605g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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