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Article

O2 -independent demethylation of trimethylamine N-oxide by Tdm of Methylocella silvestris.

The FEBS journal - 1 Nov 2016

Zhu Yijun, Ksibe Amira Z, Schäfer Hendrik, Blindauer Claudia A, Bugg Timothy D H, Chen Yin

Abstract excerpt

Bacterial trimethylamine N-oxide (TMAO) demethylase, Tdm, carries out an unusual oxygen-independent demethylation reaction, resulting in the formation of dimethylamine and formaldehyde. In this study, site-directed mutagenesis, homology modelling and metal analyses by inorganic mass spectrometry have been applied to gain insight into metal stoichiometry and underlying catalytic mechanism of Tdm of Methylocella...

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PMID: 27644004
DOI: 10.1111/febs.13902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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