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Article

Role of active site residues and solvent in proton transfer and the modulation of flavin reduction potential in bacterial morphinone reductase.

The Journal of biological chemistry - 22 Jul 2005

Messiha Hanan L, Bruce Neil C, Sattelle Benedict M, Sutcliffe Michael J, Munro Andrew W, Scrutton Nigel S

Abstract excerpt

The reactions of several active site mutant forms of bacterial morphinone reductase (MR) with NADH and 2-cyclohexen-1-one as substrates have been studied by stopped-flow and steady-state kinetic methods and redox potentiometry. The enzymes were designed to (i) probe a role for potential proton do...

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Identifiers

PMID: 15905167
DOI: 10.1074/jbc.M502293200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15905167-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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