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Article

Pleiotropic functional properties of androgen receptor mutants in prostate cancer.

Human mutation - 1 Feb 2009

Bergerat Jean-Pierre, Céraline Jocelyn

Abstract excerpt

The androgen receptor (AR) signaling pathway plays an important role during the development of the normal prostate gland, but also during the progression of prostate cancer on androgen ablation therapy. Mutations in the AR gene emerge to keep active the AR signaling pathway and to support prostate cancer cells growth and survival despite the low levels of circulating androgens. Indeed, mutations affecting the...

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Identifiers

PMID: 18800375
DOI: 10.1002/humu.20848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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