Article
A G577R mutation in the human AR P box results in selective decreases in DNA binding and in partial androgen insensitivity syndrome.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 2001
Nguyen D, Steinberg S V, Rouault E, Chagnon S, Gottlieb B, Pinsky L, Trifiro M, Mader S
Abstract excerpt
We have characterized a novel mutation of the human AR, G577R, associated with partial androgen insensitivity syndrome. G577 is the first amino acid of the P box, a region crucial for the selectivity of receptor/DNA interaction. Although the equivalent amino acid in the GR (also Gly) is not involved in DNA interaction, the residue at the same position in the ER (Glu) interacts with the two central base pairs in...
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