Article
Frequency of natural regulatory CD4+CD25+ T lymphocytes determines the outcome of tolerance across fully mismatched MHC barrier through linked recognition of self and allogeneic stimuli.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2006
Fucs Rita, Jesus Joszilene T, Souza Junior Paulo H N, Franco Larissa, Verícimo Mauricio, Bellio Maria, Nobrega Alberto
Abstract excerpt
We show in this study that long-term tolerance to allogeneic skin grafts can be established in the absence of immunosuppression by the combination of the following elements: 1) augmenting the frequency of regulatory CD4(+)CD25(+) T cells (Treg) and 2) presentation of the allogeneic stimuli through linked recognition of allo- and self-epitopes on semiallogeneic F(1) APCs. BALB/c spleen cells enriched for...
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