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CD25+ immunoregulatory T-cells of donor origin suppress alloreactivity after BMT

1 Oct 2002

Abstract excerpt

We have previously identified donor-derived Thy1+ alphabeta T-cell receptor (TCR)+ CD4+ CD8- regulatory T-cells that suppress GVH reactivity induced by donor leukocyte infusion (DLI) after BMT. These cells develop in the recipient thymus and may play a role in the maintenance of donor-host tolerance after allogeneic BMT. In the present study, we sought to further characterize the T-cells responsible for the...

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PMID: 12434947
DOI: 10.1053/bbmt.2002.v8.pm12434947

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