Article
Influences of obese (ob/ob) and diabetes (db/db) genotype mutations on lumber vertebral radiological and morphometric indices: skeletal deformation associated with dysregulated systemic glucometabolism.
BMC musculoskeletal disorders - 1 Feb 2006
Burkemper Katherine M, Garris David R
Abstract excerpt
BACKGROUND: Both diabetes and obesity syndromes are recognized to promote lumbar vertebral instability, premature osteodegeneration, exacerbate progressive osteoporosis and increase the propensity towards vertebral degeneration, instability and deformation in humans. METHODS: The influences of single-gene missense mutations, expressing either diabetes (db/db) or obese (ob/ob) metabolic syndromes on vertebral...
Topics
- Animals
- Bone Development
- Diabetes Mellitus, Type 2
- Estradiol
- Female
- Genotype
- Glucose
- Lumbar Vertebrae
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains