Article
Identifying genetic variation affecting a complex trait in simulated data: a comparison of meta-analysis with pooled data analysis.
BMC genetics - 30 Dec 2005
Wu Xiaodong, Kan Donghui, Cooper Richard S, Zhu Xiaofeng
Abstract excerpt
We explored the power and consistency to detect linkage and association with meta-analysis and pooled data analysis using Genetic Analysis Workshop 14 simulated data. The first 10 replicates from Aipotu population were used. Significant linkage and association was found at all 4 regions containing the major loci for Kofendrerd Personality Disorder (KPD) using both combined analyses although no significant linkage...
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