Article
Pilot study of the G-protein beta3 subunit gene (C825T) polymorphism and clinical response to olanzapine or olanzapine-related weight gain in persons with schizophrenia.
Medical science monitor : international medical journal of experimental and clinical research - 1 Feb 2006
Bishop Jeffrey R, Ellingrod Vicki L, Moline Jessica, Miller Del
Abstract excerpt
BACKGROUND: Despite advances in schizophrenia treatment, nearly 30% of patients do not respond to atypical antipsychotic agents, such as olanzapine. Furthermore, 30-60% of patients will gain significant weight during the course of olanzapine therapy. Little research has been done to investigate the relationship between antipsychotic treatment outcomes and genetic variability in second messengers coupled to...
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