Tracing the origins of human voltage-gated K ⁺ channels: where they come from and what we lost along the way

Abstract excerpt

<h4>ABSTRACT</h4> Humans have 40 voltage-gated K + channel (Kv) genes that are broadly conserved in vertebrate model organisms and spread across three ancient gene families (KCNQ, EAG and Shaker). We used deep coverage phylogenetic analyses to trace the evolutionary origins of each human Kv channel. 39/40 human channels were already present in the common ancestor of jawed vertebrates (gnathostomes) and as many a...

Topics

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• Cardiac electrophysiology and arrhythmias
• Evolution, Molecular
• Genetic Variation
• Hippocampus
• Ion channel regulation and function
• Mutation
• Neurons
• Potassium Channels, Voltage-Gated

Identifiers and source

Literature Corpus work

99b36ba3-5846-54bf-8c8a-1693713ddf57

DOI

10.1101/2025.09.21.677649