Assessing mitochondrial phenotypes in a cybrid model of dry age-related macular degeneration.

doi:10.63500/mv_v32_196

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Article

Assessing mitochondrial phenotypes in a cybrid model of dry age-related macular degeneration.

Molecular vision - 1 Jan 2026

Dohl Jacob, Zaw Nyan Lin, Nguyen Jett, Burns Gordon, Park Brandon, Atilano Shari, Schneider Kevin, Chwa Marilyn, Kenney Maria Cristina

Abstract excerpt

Purpose: Dry age-related macular degeneration (DAMD) is the leading cause of vision loss in developed countries, yet there are no FDA-approved treatments currently available. Mitochondria play a significant role in the pathology of DAMD; the retinal pigment epithelium cells of patients with DAMD exhibit mitochondrial dysfunction, elevated levels of mitochondrial DNA lesions, and increased mitochondrial reactive...

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Topics

Humans
Mitochondria
DNA, Mitochondrial
Phenotype
Retinal Pigment Epithelium
Geographic Atrophy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Hybrid Cells

Membrane Potential, Mitochondrial

Oxygen Consumption

Cell Line

Blood Platelets

Mitochondrial Proteins

Reactive Oxygen Species

Macular Degeneration

Source

Open in PubMed Open full text

Identifiers

PMID: 42774060
DOI: 10.63500/mv_v32_196
PMCID: PMC13585426

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