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Article

Peroxisomal abnormalities and catalase deficiency in Hutchinson-Gilford Progeria Syndrome.

Aging - 18 Mar 2020

Mao Xiaojing, Bharti Pratima, Thaivalappil Abhirami, Cao Kan

Abstract excerpt

Peroxisomes are small, membrane-enclosed eukaryotic organelles that house various enzymes with metabolic functions. One important feature in both Hutchinson-Gilford Progeria Syndrome (HGPS) and normal aging is the elevated levels of Reactive Oxygen Species (ROS), which are generated from metabolic pathways with the capacity to cause oxidative damage to macromolecules within the cells. Although peroxisomal...

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Identifiers

PMID: 32186522
DOI: 10.18632/aging.102941
PMCID: PMC7138560

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